Lockheed sees material effect of budget cuts on sales, earnings

WASHINGTON, Feb 28 (Reuters - Lockheed Martin Corp, the Pentagon's largest supplier, on Thursday said its programs could be materially reduced, delayed or canceled if Congress does not avert across-the-board budget cuts due to take effect Friday, which would drive sales and earnings lower than projected.

If the reductions do take effect, Lockheed said its 2013 sales would drop more than the current outlook, which forecast a decline in the mid single-digit percentage range on the assumption that the automatic budget cuts would be averted.

Earnings and cash flow would follow a similar pattern, the company said in its annual report filed Thursday with the U.S. Securities and Exchange Commission. It said financial results in future years could also be materially affected.

Lockheed said 82 percent of its net revenues of $47.2 billion came from U.S. government customers in 2012, including 61 percent from the U.S. Department of Defense. The company reported earnings per share of $8.48 in 2012, up from $7.94 a year earlier.

Lockheed shares closed 33 cents lower at $88.00 on the New York Stock Exchange on Thursday.

In a separate development, the Pentagon on Thursday awarded Lockheed a $333.8 million fixed-price contract to pay for advanced procurement of materials needed to build an eighth batch of F-35 fighter jets.

In its daily digest of major weapons contracts, the Pentagon said the funds would allow Lockheed to buy long lead-time parts, materials and components for 35 jets that are due to be built the U.S. military, Britain and Norway.

Lockheed and the U.S. government reached an agreement in principle in December on the sixth and seventh production lots of F-35 planes, but are still working out the details of those contracts.

Negotiations have not yet begun about the eighth batch of jets, but the Pentagon regularly awards contractors funding to buy rare metals and other components that take a long time to procure.

(Reporting By Andrea Shalal-Esa; Editing by Leslie Adler and David Gregorio)

Source: http://news.yahoo.com/lockheed-sees-material-effect-budget-cuts-sales-earnings-231435057--finance.html

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Broccoli Boosts Liver Detox Enzymes | Care2 Healthy Living

Researchers just found out that the boost in detoxifying enzymes triggered by cruciferous vegetable consumption may last for weeks!

Last spring in my Care2 post The Best Detox I described this amazing phenomenon in which a phytonutrient produced by broccoli can enhance the function of our so-called phase II enzyme system that aids in the excretion of foreign molecules. For example if you feed people broccoli and Brussels sprouts, they clear caffeine quicker as you can see if you click on the above video. This means that if you eat a lot of these healthy vegetables you?d actually have to drink more coffee to get the same buzz because your liver is so revved up.

15 Ways to Use Broccoli

What about the carcinogens that I wrote about in my last three posts, Estrogens in Cooked Meat, Avoiding Cooked Meat Carcinogens, and Cancer Growth Blockers: Green Tea & Garlic? In the studies on Long Island, women that established increased breast cancer risk in those eating grilled meats found that the risk appeared greatest in women with the low fruit and vegetable consumption. Maybe having a side of broccoli can help your body deal with the carcinogen load? Researchers decided to put it to the test.

In the above video I detail a study in which subjects were fed cooked meat meals with and without broccoli and Brussels sprouts. You can see how dramatically the levels of these carcinogenic compounds circulating in their bodies drops. Now this wasn?t a surprise; that?s what cruciferous vegetables do?boost our liver?s ability to clear chemicals from our body. What blew the researchers away was the fact that when the veggies were taken away liver function remained enhanced?even two weeks later.

So there appears to be a prolonged beneficial effect of cruciferous vegetable consumption. You can eat broccoli days or even weeks before the big barbeque and still retain some protection. Of course if you grill veggie burgers instead it would be a non-issue. Since heterocyclic amines are byproducts of muscle tissue reacting to high heat, you can even deep-fry plant foods and still none of these carcinogens are formed.

For more on broccoli?s superpowers see my video Sometimes the Enzyme Myth Is True. You can overdo it, but apparently only at extremely high doses (see?Liver Toxicity Due to Broccoli Juice, Overdosing on Greens, and?How Much Broccoli Is Too Much?).

In health,
Michael Greger, M.D.

PS: If you haven?t yet, you can subscribe to my videos for free by clicking here and watch my full 2012 year-in-review presentation?Uprooting the Leading Causes of Death.

Image credit: [puamelia] via Flickr, and Dhaluza and David.Monniaux via Wikimedia Commons.

Related:
Eating Green to Prevent Cancer
How Do Plant-Based Diets Fight Cancer?
Breast Cancer Stem Cells vs. Broccoli

Source: http://www.care2.com/greenliving/broccoli-boosts-liver-detox-enzymes.html

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Virus shows promise as prostate cancer treatment

Tuesday, February 26, 2013

A recombinant Newcastle disease virus kills all kinds of prostate cancer cells, including hormone resistant cells, but leaves normal cells unscathed, according to a paper published online ahead of print in the Journal of Virology. A treatment for prostate cancer based on this virus would avoid the adverse side effects typically associated with hormonal treatment for prostate cancer, as well as those associated with cancer chemotherapies generally, says corresponding author Subbiah Elankumaran of Virginia Polytechnic Institute, Blacksburg. The modified virus is now ready to be tested in preclinical animal models, and possibly in phase I human clinical trials.

Newcastle disease virus kills chickens, but does not harm humans. It is an oncolytic virus that hones in on tumors, and has shown promising results in a number of human clinical trials for various forms of cancer. However, successful treatments have required multiple injections of large quantities of virus, because in such trials the virus probably failed to reach solid tumors in sufficient quantities, and spread poorly within the tumors.

The researchers addressed this problem by modifying the virus's fusion protein. Fusion protein fuses the virus envelope to the cell membrane, enabling the virus to enter the host cell. These proteins are activated by being cleaved by any of a number of different cellular proteases. They modified the fusion protein in their construct such that it can be cleaved only by prostate specific antigen (which is a protease). That minimizes off-target losses, because these "retargeted" viruses interact only with prostate cancer cells, thus reducing the amount of virus needed for treatment.

Retargeted Newcastle disease virus has major potential advantages over other cancer therapies, says Elankumaran. First, its specificity for prostate cancer cells means it would not attack normal cells, thereby avoiding the various unpleasant side effects of conventional chemotherapies. In previous clinical trials, even with extremely large doses of naturally occurring strains, "only mild flu-like symptoms were seen in cancer patients," says Elankumaran. Second, it would provide a new treatment for hormone-refractory patients, without the side effects of testosterone suppression that result from hormonal treatments.

About one man in six will be diagnosed with prostate cancer, and one in 36 will die of this disease. Men whose prostate cancer becomes refractory to hormone treatment have a median survival of about 40 months if they have bone metastases, and 68 months if they do not have bone metastases.

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Paper: http://www.asm.org/images/Communications/tips/2013/0213prostate.pdf

American Society for Microbiology: http://www.asm.org

Thanks to American Society for Microbiology for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127018/Virus_shows_promise_as_prostate_cancer_treatment

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Energy policy shifting as abundance replaces scarcity: Obama adviser

WASHINGTON (Reuters) - As U.S. oil and natural gas production booms, the Obama administration's energy policy has been "fluid" by necessity to adapt to the huge economic opportunities and climate challenges posed by growth, the top White House energy and climate adviser said on Wednesday.

In a speech to a room packed with energy analysts and lobbyists, Obama adviser Heather Zichal acknowledged that U.S. energy policy "might not look perfectly pretty from the outside" as it evolves to shifting supply-and-demand scenarios.

"It is a little bit fluid, but the landscape is changing," Zichal said at the Center for Strategic and International Studies, a Washington think-tank.

The White House wants to ensure oil and gas production is done as safety as possible, while investing in research and development of renewable forms of energy and addressing climate change, she said.

"I think that those goals will really help this administration deliver on an energy policy that makes a lot of sense," Zichal said.

"Energy is the common thread that links these three issues: our economy, our security and our climate," she said.

SHALE REVOLUTION

Hydraulic fracturing, or "fracking," has blasted massive new supplies of oil and natural gas from shale rock deep beneath the earth. After decades of policies built around being dependent on imports of foreign oil, lawmakers and the administration are grappling with whether and how to allow more exports.

The United States could surpass Saudi Arabia as the world's top oil producer by 2017, and within years could become a net exporter of natural gas.

Zichal noted the administration is finalizing new rules for disclosing chemicals used in fracking on public lands, and tougher standards for fracking wells and wastewater.

"We're not glossing over the challenges of natural gas development, but we're also not ignoring the opportunity natural gas presents for jobs and for the climate," she said.

The White House recognizes the impact oil and natural gas production has had on the economy, creating jobs and bringing manufacturing operations from companies like Dow Chemical Co and Ford Motor Co back from overseas, Zichal said.

She did not shed new light on how the administration will rule on permitting exports to more countries, decisions expected sometime this year. Zichal repeated that the White House is "not opposed to the notion of exports" but wants to ensure they don't "undermine" American consumers.

Zichal said she is spending "a lot of time talking to the rail industry" about infrastructure needs to move a glut of oil from the U.S. Midwest to refineries on the coast, another outcome of the sudden bounty of oil supplies.

But she shied away from discussing White House thinking on the Keystone XL pipeline, a project designed to ship oil from Canada and North Dakota to Gulf refineries.

Zichal said the decision-making process is in the hands of the State Department. The project has been stalled for years pending a decision by the administration.

(Reporting by Roberta Rampton; Editing by Lisa Shumaker)

Source: http://news.yahoo.com/energy-policy-shifting-abundance-replaces-scarcity-obama-adviser-033947160.html

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